diff --git a/meson.build b/meson.build
index 058382046e1..725e10d815c 100644
--- a/meson.build
+++ b/meson.build
@@ -909,6 +909,12 @@ if not perlopt.disabled()
 
     if host_system == 'windows'
       perl_ccflags += ['-DPLPERL_HAVE_UID_GID']
+
+      if cc.get_id() == 'msvc'
+        # prevent binary mismatch between MSVC built plperl and Strawberry or
+        # msys ucrt perl libraries
+        perl_ccflags += ['-DNO_THREAD_SAFE_LOCALE']
+      endif
     endif
 
     message('CCFLAGS recommended by perl: @0@'.format(perl_ccflags_r))