diff --git a/crypto/bio/bss_file.c b/crypto/bio/bss_file.c
index 4f79c32bbb..6af2d9cb87 100644
--- a/crypto/bio/bss_file.c
+++ b/crypto/bio/bss_file.c
@@ -73,7 +73,11 @@ BIO *BIO_new_file(const char *filename, const char *mode)
     if (file == NULL) {
         SYSerr(SYS_F_FOPEN, get_last_sys_error());
         ERR_add_error_data(5, "fopen('", filename, "','", mode, "')");
-        if (errno == ENOENT)
+        if (errno == ENOENT
+# ifdef ENXIO
+            || errno == ENXIO
+# endif
+            )
             BIOerr(BIO_F_BIO_NEW_FILE, BIO_R_NO_SUCH_FILE);
         else
             BIOerr(BIO_F_BIO_NEW_FILE, ERR_R_SYS_LIB);