diff --git a/Configure b/Configure
index 66507039cd..62c354abf0 100755
--- a/Configure
+++ b/Configure
@@ -1415,9 +1415,11 @@ if (!$disabled{makedepend}) {
         # For VC- and vms- targets, there's nothing more to do here.  The
         # functionality is hard coded in the corresponding build files for
         # cl (Windows) and CC/DECC (VMS).
-    } elsif ($predefined{__GNUC__} >= 3) {
+    } elsif (($predefined{__GNUC__} // -1) >= 3
+	     && !($predefined{__APPLE_CC__} && !$predefined{__clang__})) {
         # We know that GNU C version 3 and up as well as all clang
-        # versions support dependency generation
+        # versions support dependency generation, but Xcode did not
+        # handle $cc -M before clang support (but claims __GNUC__ = 3)
         $config{makedepprog} = "\$(CROSS_COMPILE)$config{CC}";
     } else {
         # In all other cases, we look for 'makedepend', and disable the